2016 Fiscal Year Final Research Report
Analysis of a novel factor associated with short stature and application to therapy
| Project/Area Number |
26670494
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 低身長 / モデル動物 / 発症機序 |
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| Outline of Final Research Achievements |
Short stature is one of the most common symptoms in pediatric endocrine diseases. We recently found a novel factor responsible for a disease presenting with extreme short stature. In this study, we analyzed the mechanism of this factor related to bone growth. We overexpressed this factor in a cultured cell line and evaluated the cell growth, cell differentiation, and marker proteins. We found that this factor had a repressive effect on chondrocyte growth and differentiation. The repressive effect was increased in the mutants. Furthermore, we have created model animals to investigate the function of this factor in vivo.
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| Free Research Field |
小児科学
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