2015 Fiscal Year Final Research Report
Development of therapy for skin diseases by utilizing regulatory B cells
| Project/Area Number |
26670521
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
|
|---|
| Research Institution | University of Tsukuba |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 免疫 |
|---|
| Outline of Final Research Achievements |
Microarray analysis suggested that PTEN is involved in the signal transduction of regulatory B cell development. Conditional kick-out mice that has no PTEB expression specifically in B cells were generated. In this mouse, a novel regulatory B cell subset was identified in B-1 cell population. This subset has potent suppressing capability in various immune responses, and thus is considered as a potential target in treating autoimmune diseases and cancers. Additionally, new cell surface markers for regulatory B cells are identified.
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| Free Research Field |
皮膚科学
|
