Development of a novel molecular target therapy that can suppress melanoma progression

2017 Fiscal Year Final Research Report

• Project/Area Number: 26670525
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: Masashi Kato 名古屋大学, 医学系研究科, 教授 (10281073)
• Co-Investigator(Kenkyū-buntansha): 武田 湖州恵 中部大学, 生命健康科学部, 准教授 (80345884)
• Co-Investigator(Renkei-kenkyūsha): YAJIMA Ichiro 名古屋大学, 医学系研究科, 講師 (80469022)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: メラノーマ / バイオマーカー / 分子標的療法 / 動物モデル

Outline of Final Research Achievements

We previous developed RET-transgenic mice (RET-mice), in which development of hyperpigmented skin and benign melanocytic tumors at about 100% and development of melanoma at about 65%. In this study, we first selected molecules after performing microarray analysis using benign tumor and melanoma developed in RET-mouse. We then performed functional analysis for these three molecules. The molecules are involved in the regulation for anchorage- independent growth, invasion and metastasis. Thus, we have not only proposed plural candidate molecules that are available as a biomarker of melanoma but also provided basic data for developing a molecular target therapy that suppress melanoma proliferation, infiltration and metastasis.

Free Research Field

皮膚科学