Development of novel therapeutic strategy for skin diseases by utilizing anti-inflammatory activity of circulating mesenchymal stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670531
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: TAMAI Katsuto 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (20236730)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: HMGB1 / 間葉系幹細胞 / 接触性皮膚炎

Outline of Final Research Achievements

In this study, we aimed to develop a novel anti-inflammatory therapy for allergic contact dermatitis by utilizing anti-inflammatory activity of bone marrow mesenchymal stem cells (MSCs), which were mobilized from bone marrow into the circulation by high mobility group box 1 (HMGB1). Systemic administration of HMGB1 to contact hypersensitivity model mouse showed significant anti-inflammatory effect by inducing accumulation of bone marrow-derived MSCs in the skin lesion. We further elucidated that CXCR4/SDF-1 axis was involved in the accumulation of circulating MSCs into the lesion, and that inoculated HMGB1 induced expression of CXCR4, a receptor for chemokine SDF-1, on the MSC surface. These results indicate that systemically administered HMGB1 suppresses inflammatory reactions not only by inducing mobilization of MSCs from bone marrow into circulation, but also by accelerating accumulation of the circulating MSCs into the inflammatory/injured tissues by enhancing CXCR4/SDF-1 axis.

Free Research Field

皮膚科学、再生医療学、遺伝子治療学