Novel neural mechanisms of active control for the monoaminergic/cholinergic release

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670534
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hokkaido University
• Principal Investigator: Yoshida Takayuki 北海道大学, 医学(系)研究科(研究院), 助教 (60374229)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Masahiko 北海道大学, 医学研究科, 教授 (70210945) ; OHMURA yu 北海道大学, 医学研究科, 助教 (80597659)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 扁桃体 / セロトニン / カンナビノイド / ドーパミン / ストレス

Outline of Final Research Achievements

Endocannabinoids were produced by activation of postsynaptic serotonin (5-HT) receptor as well as decreased presynaptic 5-HT release by the activation of the CB1 receptor in the amygdala. We demonstrated that it was caused by calcium- and neuronal activity-dependent manner. In addition, it was revealed that excitability of the pyramidal neuron in the adult amygdala was enhanced by aversive stress at juvenile periods and by activations of 5-HTergic receptors. We also revealed that the 5-HT7 receptor of CA3 pyramidal cell in the ventral hippocampus participated in recalls of the fear memory through the activation of Ih current.

Free Research Field

神経科学