2015 Fiscal Year Final Research Report
Biological markers of plasma protein glycosylation in major depressive disorder
| Project/Area Number |
26670542
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | うつ病 / バイオマーカー / 糖鎖 |
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| Outline of Final Research Achievements |
Glycosylation is one of the most common posttranslational modifications that occur during protein biosynthesis, and protein glycosylation is a major contributor to many diseases. However, the mechanisms of protein glycosylation in the pathophysiology of major depressive disorder have not been elucidated. We analyzed plasma protein glycosylation using a lectin microarray, and also examined protein plasma glycosylation in a mouse model of depression. Our results describe lectins that are associated with depression and stress.
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| Free Research Field |
精神医学
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