2017 Fiscal Year Final Research Report
Histological analysis of the radiosensitizing effects of hydrogen peroxide through the resolution of endogenous peroxidase
| Project/Area Number |
26670561
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
稗田 洋子 島根大学, 医学部, 助教授 (00181058)
玉置 幸久 島根大学, 医学部, 講師 (40457099)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | hydrogen peroxide / radiation therapy / radiosensitizer |
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| Outline of Final Research Achievements |
The anti-tumor effects of radiation therapy in combination with hydrogen peroxide were analyzed.
For superficial and exposed tumors, hydrogen peroxide soaked gauze was put on the tumor’s surface each time just before irradiation. For non-dermatological tumors, hydrogen peroxide containing sodium hyaluronate was injected homogeneously into the tumor twice a week after delivering 20Gy. The total dose ranged from 18Gy to 66Gy.
The anti-tumor effects of hydrogen peroxide were excellent and 90% of the patients achieved complete or good response. The radiosensitizing effect was predominant especially in the radio resistant tumors that were irradiated without hydrogen peroxide. The histological findings observed in the tumor was mainly composed of sever necrosis.
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| Free Research Field |
放射線腫瘍学
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