2015 Fiscal Year Final Research Report
Development of the molecular targeted therapy for the chronic rejection after renal transplantation that control immunological memory
| Project/Area Number |
26670575
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 免疫系受容体 / 慢性拒絶反応 / 腎移植 / 免疫記憶 / 分子標的療法 |
|---|
| Outline of Final Research Achievements |
For the prevention of the chronic rejection after renal transplantation, the polypharmacy of the immunosuppressive drug for a long term is provided. However, the long-term dosage of the immunosuppressive drugs results in the immunodeficiency.
It is known that chronic inflammation induced by the alloantigen-specific memory T cells is one of the causes of the chronic rejection. Here, we show that DNAM-1 plays an important role in generation of alloantigen-specific memory of immunity by using DNAM-1-deficient mice. Moreover, we observed that fibrosis of the kidney after renal transplantation was much milder in DNAM-1-deficient mice compared with those in wild-type mice. These results suggest that DNAM-1 might be a good molecular target for prevention of the chronic rejection after the renal transplantation.
|
| Free Research Field |
免疫学、臨床免疫学
|
