The role of central-mediated hepatic responses in the obesity-induced impediment of hepatic regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670599
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kanazawa University
• Principal Investigator: Inoue Hiroshi 金沢大学, 新学術創成研究機構, 教授 (50397832)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 外科 / 肝切除 / 脂肪肝

Outline of Final Research Achievements

Brain-mediated hepatic responses, including gluconeogenic suppression, are mediated by the vagus nerve and hepatic IL-6/STAT3 activation. Meanwhile, hepatic STAT3 is known as the master regulator of hepatic regeneration, controlling the expressions of anti-apoptotic genes and cell-cycle related genes. In this project, we elucidate the mechanism of how brain regulates the vagus nerve and hepatic STAT3 activation. Further, we have found that the central-mediated hepatic responses are impeded in obesity. While hepatic regeneration is impaired in insulin-resistance and obesity, the impeded brain-mediated hepatic responses may be related to the obesity-induced dysfunction of hepatic regeneration.

Free Research Field

代謝学・食生活学