The characteristics of a new tumor associated antigen, Kita-kyushu lung cancer antigen-1(KK-LC-1)

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670609
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2015-2016); Kitasato University (2014)
• Principal Investigator: Futawatari Nobue 独立行政法人国立病院機構(相模原病院臨床研究センター), 外科, 医長 (40306600)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌 / 癌/精巣抗原 / KK-LC-1 / Helicobacter pylori / メチル化

Outline of Final Research Achievements

There were few report about KK-LC-1 except for lung cancer. This study showed that KK-LC-1 was expressed in gastric cancer and its expression rate was 82% （Shida A, Futawatari N, et al. Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer. Anticancer res 2015；35：3575-3580）. Furthermore, its high-rate expression correlated with the serum antibody against Helicobacter pylori （H. pylori）, (Fukuyama T, Futawatari N, et al. Correlation Between Expression of Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer. In Vivo 2017; 31; 403-407）. The conclusion of this study is that KK-LC-1 is one of cancer/testis antigens and its expression would be induced by infection of H. pylori.

Free Research Field

胃癌