Identification of biliary duct cancer-associated long non-coding RNAs and their diagnostic and therapeutic application

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670610
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Nippon Medical School
• Principal Investigator: TAKIZAWA Toshihiro 日本医科大学, 医学(系)研究科(研究院), 教授 (90271220)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Hiroshi 日本医科大学, 医学部, 准教授 (60246999) ; TANIAI Nobuhiko 日本医科大学, 医学部, 准教授 (20287725) ; MIZUGUCHI Yoshiaki 日本医科大学, 医学部, 助教 (70409217)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 癌 / 胆道外科学 / 胆管癌 / 胆嚢癌 / ノンコーディングRNA

Outline of Final Research Achievements

Long non-coding RNAs (lncRNAs; more than 200 nucleotides in length) are endogenous RNAs that do not code for functional proteins. Identifying tissue-specific lncRNAs is the first step toward understanding their biological functions and applying them to diagnostic and therapeutic tools. Using next-generation sequencing technologies (Illumina MiSeq and HiSeq), we performed RNA profiling of biliary duct cancer cells and their cell lines to elucidate the characteristics of the lncRNAs expressed in biliary duct cancer.

Free Research Field

分子腫瘍学（肝胆道系腫瘍）、分子病理解剖学、胎盤学