Possible interplay between metabolism and genomic instability during epithelial oncogenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670611
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: SHIIBA KENICHI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (90196345)
• Co-Investigator(Kenkyū-buntansha): SHIMA Hiroshi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462) ; TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: がん / 代謝 / ワールブルグ効果

Outline of Final Research Achievements

Possible interplay between metabolism and genomic instability during epithelial oncogenesis have been evaluated. We isolated and purified epithelial cells of Pkm gene-targeting mice, then transformed them by active mutants of Kras and EGFR. Transplantation experiments of these cells into nude mice revealed important roles for metabolic remodeling directed by Pkm.

Free Research Field

大腸外科学