2016 Fiscal Year Final Research Report
Development of protection for spinal cord ischemic injury with oxygenation of the cerebrospinal fluid applying nanobubble generation technique.
| Project/Area Number |
26670615
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 胸腹部大動脈瘤 / 対麻痺 / ナノバブル / 脳脊髄液酸素化 / 虚血性脊髄障害 |
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| Outline of Final Research Achievements |
A purpose of this study was to develop a preventive method against spinal cord ischemic injury after thoracoabdominal aneurysm repair. We applied nanobubble generation technique to oxygenation of fluid and produced oxygenated artificial cerebrospinal fluid. Continuously infusing it into intrathecal space in rabbit model made cerebrospinal fluid-pO2 increased. And, under this condition, we confirmed that motor function of rabbit’s lower limb was preserved correlating with increasing of cerebrospinal fluid-pO2 when we occluded its abdominal aorta with a balloon catheter and induced spinal cord ischemia. From the above, we concluded that oxygenation of the cerebrospinal fluid with nanobubbles can ameliorate a spinal cord ischemic injury in a rabbit model. Modifications of CSF using nanobubble technology deserve to be considered as a novel strategy for spinal cord protection.
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| Free Research Field |
心臓大血管外科、補助人工心臓、心臓移植
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