Deciphering molecular pathogenesis of aortic dissection: the role of stress sensor molecules

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670621
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Kurume University
• Principal Investigator: AOKI Hiroki 久留米大学, 循環器病研究所, 教授 (60322244)
• Co-Investigator(Kenkyū-buntansha): KANAYAMA Shuri 昭和大学, 医学部, 講師 (10338535) ; TANAKA Hiroyuki 久留米大学, 医学部, 教授 (70197466)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 大動脈解離 / ストレス応答 / 遺伝子発現

Outline of Final Research Achievements

Aortic dissection is a medical emergency, in which patients frequently suffer from a sudden death. Currently, no specific non-surgical therapy is available for aortic dissection, because the etiology and pathogenesis is largely unknown. In this study we demonstrated that MRTF-A, an intracellular stress sensor, translates the mechanical and humoral stress to the tissue destructive response that eventually causes aortic dissection. MRTF-A inhibitor effectively prevented the development of aortic dissection, showing that MRTF-A is a promising therapeutic target.

Free Research Field

分子循環器学