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2015 Fiscal Year Final Research Report

Comprehensive kinome analysis of metastatic activity in lung cancer cells

Research Project

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Project/Area Number 26670626
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionKyoto University

Principal Investigator

DATE Hiroshi  京都大学, 医学(系)研究科(研究院), 教授 (60252962)

Co-Investigator(Kenkyū-buntansha) MENJYU Toshi  京都大学, 大学院医学研究科, 助教 (30527081)
Project Period (FY) 2014-04-01 – 2016-03-31
KeywordsKinome / 肺癌転移能
Outline of Final Research Achievements

The molecular markers associated with tumor metastasis were compared between the parental lung cancer cell lines and the highly metastatic cells which were induced by in vivo selection methods. Highly metastatic cells originated from PC14 showed the loss of E-cadherin expression and the gain of Vimentin expression, showing its EMT phenotype. The other three cells did not show such phenomenon. The kinome analysis could not be performed due to its patent problem.

Free Research Field

呼吸器外科

URL: 

Published: 2017-05-10  

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