PET measurement of cerebral blood flow and opioid ligand during the exercise of patients with CVD.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670637
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Nariai Tadashi 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00228090)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: PET / 有酸素運動 / 脳血流 / もやもや病 / 脳梗塞 / O-15 水 / オピオイド受容体 / 辺縁系

Outline of Final Research Achievements

We conducted PET researches to establish optimum exercise protocol for patients with CVD. 5 patients with occlusion of cerebral major arteries were recruited. CBF was quantitated by O-15 wate PET during resting state, 3 min and 13 min after the initiation of cycling exercise, and 2 min after its cessation. Result was compared with that of normal controls. There was no difference between pateints' and control's CBF response during exercise. Instead, CBF decrease after the cessation of exercise not in patients but in controls.
Another PET study to measure the activation of brain opioid system during exercise was conducted in normal subjects. C-11 carfentanil, a ligand to measure μopioid receptor, was injected in resting condition and after exercise. Significant reduction of binding potential was observed mainly among limbic system presumably reflecting activation of endogenous opioid system. Reduction rate significantly correlated with the degree of reduction in depression score.

Free Research Field

脳神経外科学