Molecular subclassification of glioblastoma based on the absolute quantitative proteomics

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670638
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: NAKADA MITSUTOSHI 金沢大学, 医学系, 教授 (20334774)
• Co-Investigator(Renkei-kenkyūsha): TERASAKI TETSUYA 東北大学, 薬学部, 教授 (60155463)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 膠芽腫 / プロテオミクス / チロシンキナーゼ / 分類

Outline of Final Research Achievements

The purpose of this study is to attempt to classify GBM subtypes based on the molecular profile determined by absolute quantitative proteomics and to investigate its clinical significance. GBMs in our study harbored mutually exclusive dominant expression of three RTKs; EGFR, PDGFRα and ERBB2. Therefore, we propose a subclassification of GBM with respect to the dominant expression of these proteins; EGFR (n=25), PDGFRα (n=11) and ERBB2 (n=7). PFS and OS tended to be longer in ERBB2 group in comparison with EGFR and PDGFRα group. Molecular subclassification of GBM based on the absolute quantitative proteomics reflects the clinical behavior and might have clinical significance.

Free Research Field

脳神経外科学、脳腫瘍学