Transcriptome analysis for primary central nervous system lymphomas.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670646
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Ryuya YAMANAKA 京都府立医科大学, 医学部, 教授 (20323991)
• Co-Investigator(Kenkyū-buntansha): IKENAKA Kazuhiro 生理学研究所, 分子神経生理部門, 教授 (00144527) ; KAWAGUCHI Atsush 佐賀大学, 医学部, 教授 (60389319) ; HAYANO Azusa 京都府立医科大学, 医学研究科, 博士研究員 (10379018)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脳リンパ腫 / ゲノム解析 / トランスクリプトーム解析 / 分子標的療法

Outline of Final Research Achievements

To delineate the genetic basis of PCNSL pathogenesis, we performed a comprehensive genetic study. We first analyzed tumor total RNA from 30 PCNSL cases by transcriptome sequencing. We are now doing analysis using super computer to verify fusion genes and to validate coding and non-codong RNA expression level.

Free Research Field

脳神経外科学、臨床腫瘍学