2015 Fiscal Year Final Research Report
Identification of functional glyco-biomarkers during chondrogenesis of mouse iPS cells
Project/Area Number |
26670652
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | Hokkaido University |
Principal Investigator |
Iwasaki Norimasa 北海道大学, 医学(系)研究科(研究院), 教授 (30322803)
|
Co-Investigator(Kenkyū-buntansha) |
ONODERA Tomohiro 北海大学, 大学病院, 講師 (70547174)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 幹細胞 / 軟骨細胞分化 / 糖鎖 |
Outline of Final Research Achievements |
Alterations in the structure of stem cell surface glycoforms were found during chondrogenesis. Based on the obtained results, several glycans are considered to play important roles in stem cell-derived chondrogenesis. The identified glycans have functional potential of chondrogenic biomarkers for the safety of cartilage regenerative medicine.
|
Free Research Field |
整形外科学
|