2015 Fiscal Year Final Research Report
Identification of functional glyco-biomarkers during chondrogenesis of mouse iPS cells
| Project/Area Number |
26670652
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
Iwasaki Norimasa 北海道大学, 医学(系)研究科(研究院), 教授 (30322803)
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| Co-Investigator(Kenkyū-buntansha) |
ONODERA Tomohiro 北海大学, 大学病院, 講師 (70547174)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 幹細胞 / 軟骨細胞分化 / 糖鎖 |
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| Outline of Final Research Achievements |
Alterations in the structure of stem cell surface glycoforms were found during chondrogenesis. Based on the obtained results, several glycans are considered to play important roles in stem cell-derived chondrogenesis. The identified glycans have functional potential of chondrogenic biomarkers for the safety of cartilage regenerative medicine.
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| Free Research Field |
整形外科学
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