2015 Fiscal Year Final Research Report
Roles of DIO family members and thyroid hormone in articular cartilage
| Project/Area Number |
26670654
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAGAMI Ryota 東京大学, 医学部附属病院, 登録診療員 (00722191)
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| Co-Investigator(Kenkyū-buntansha) |
MORIZAKI Yutaka 東京大学, 医学部附属病院, 講師 (30508099)
TANIGUCHI Yuki 東京大学, 医学部附属病院, 助教 (80722165)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 整形外科学 / 軟骨代謝学 |
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| Outline of Final Research Achievements |
We analyzed expression patterns of DIO1, DIO2, DIO3, and thyroid hormone receptors in articular cartilage. In primary culture of articular chondrocytes, thyroid hormone promoted cell proliferation, and suppressed dedifferentiation. However, overexpression of DIO did not lead to similar results.
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| Free Research Field |
整形外科学
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