New try of bone revival using embryonic stem cell introduced bone specific promoter and reporter gene

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670669
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: University of Miyazaki
• Principal Investigator: Tomomi Ota 宮崎大学, 医学部, 医員 (80644096)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ES細胞 / 骨特異的プロモーター / トランスジーン / 骨分化特異的培養 / 骨再生

Outline of Final Research Achievements

We manufacture TransGene who connected a reporter gene to the promoter who specifically emerges to osseous tissue, and this study is intended that I examine a culture condition for differentiation to multiply it to a bone using the mouse embryonic stem cell which I introduced it into specifically and effectively.And we examine the possibility of the application to the treatment such as bone graft or the bone fracture. It is a design to connect this study with development of the new bone regenerative medicine in the near future.

Free Research Field

整形外科