2015 Fiscal Year Final Research Report
Elucidating mechanisms of altered bone matrix mineralization
| Project/Area Number |
26670674
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
MATSUO Koichi 慶應義塾大学, 医学部, 教授 (40229422)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 骨基質 / ミネラリゼーション / 石灰化 |
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| Outline of Final Research Achievements |
Bone matrix mineralization (calcification) proceeds through organized deposition of calcium hydroxyapatite crystals on collagen fibers. Both hyper- and hypomineralzation reduce bone mechanical properties. Mice lacking tyrosine kinase receptor EphA showed hypermineralization likely due to altered growth of mineralizing nodules.
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| Free Research Field |
骨代謝学
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