Therapeutic possibility of MANF, a new class of nerve growth factor, against neuropathic pain.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26670692
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Amaya Fumimasa 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60347466)
• Co-Investigator(Kenkyū-buntansha): 大橋 憲太郎 岐阜大学, 工学部, 准教授 (50332953)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 小胞体ストレス / MANF / SNL

Outline of Final Research Achievements

MANF is induced by ER stress and acts protectively in the hippocampus. In this analysis, we investigated the expression of MANF and pain hypersensitivity after the peripheral nerve injury. Rats were treated with SNL model. Pain hypersensitivity was assessed by behavioral analysis. ER stress marker and MANF expression was analyzed in the DRG.
Expression of ER stress marker and MANF was increased in SNL model. ER stress inhibitor piqfithrin reduced pain hypersensitivity and MANF expression after the SNL. Nerve injury induced ER-stress might lead to the development of neuropathic pain via MANF expression.

Free Research Field

疼痛治療医学