Development of a novel urethral reconstruction with tissue engineering

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670708
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: National Defense Medical College
• Principal Investigator: TOSHIHIRO Kushibiki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (30403158)
• Co-Investigator(Kenkyū-buntansha): HORIGUCHI Akio 防衛医科大学校, 泌尿器科学講座, 講師 (20286553) ; AZUMA Ryuichi 防衛医科大学校, 形成外科学講座, 講師 (00531112)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: 尿道再建 / 生体材料 / 上皮細胞

Outline of Final Research Achievements

The purpose of this research is to develop a new urethral reconstruction using a small mouth mucosal tissue and cell scaffold material to severe urethral stricture. Broad mouth mucosal tissue is being used as the substitute tissue for an urethral stricture, but the invasiveness to a patient is high and the risk of complications is also increased. In this study, we isolated epithelium cells from a small oral mucosal tissue and tried the identification of the factor which was necessary for the cells viability. As a result, insulin of appropriate concentration was essential to the increase of the human oral mucosal epithelium cells. It was thought that it was necessary to form an epithelium cell layer using the materials which sustained release insulin for the urethral reconstruction.

Free Research Field

生体組織工学