Analysis of the association between the collapse of cell polarity and prostate cancer development and progression by the infection.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670709
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kanagawa Academy of Science and Technology
• Principal Investigator: Ishiguro Hitoshi 公益財団法人神奈川科学技術アカデミー, 重点研究室光触媒グループ, 研究員 (00381666)
• Co-Investigator(Kenkyū-buntansha): UEMURA Hiroji 横浜市立大学, 大学病院, 准教授 (50244439)
• Co-Investigator(Renkei-kenkyūsha): KUBOTA Yoshinobu 公益財団法人神奈川科学技術アカデミー, 重点研究室光触媒グループ, 研究員 (10106312)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 前立腺癌

Outline of Final Research Achievements

We investigated to identify bacteria or virus associated with prostate cancer development and progression. In addition, we investigated that the association between prostate cancer progression and the collapse of cell polarity by the infection. As the results, we could not find specific bacteria or virus in prostate cancer tissues. On the other hand, we found that MCP-1 derived from adipocytes was an important role for prostate cancer progression. Furthermore, we found that the overexpression of atypical protein kinase C that increases the expression of inflammatory cytokines and cell polarity has the possibility for prostate cancer development.

Free Research Field

分子腫瘍学