2015 Fiscal Year Final Research Report
Investigation of molecules related in brain metastasis in Hereditary Breast and Ovarian Cancer
| Project/Area Number |
26670716
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Takayuki 新潟大学, 医歯学系, 教授 (90283754)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 婦人科腫瘍 / 遺伝性腫瘍 |
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| Outline of Final Research Achievements |
We performed SNP analysis of TGFBR2 and CTNNB1 involved in signaling pathways of epithelial mesenchymal transition (EMT) in 90 ovarian cancer cases with BRCA mutation (BRCA+ cases), 110 cases without BRCA mutation (BRCA- cases) and 170 healthy women (Control). As a result, the frequency of allele T in BRCA+ cases was significantly higher than that of BRCA- cases in SNP located at exon3 of CTNNB1 (p= 0.027). In conclusion, CTNNB1 appear to be related to brain metastasis of ovarian cancer with BRCA mutation. We plan to do further analysis of the gene in the cases with brain metastasis.
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| Free Research Field |
婦人科腫瘍
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