analysis of the amount of bleeding in delivery through morphological changes at the placental basal plate in assisted reproductive technology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670719
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: YAGUCHI CHIZUKO 浜松医科大学, 医学部附属病院, 診療助教 (20397425)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胎盤病理 / 胎盤基底膜板 / 脱落膜欠損 / 子宮筋癒着 / 生殖補助医療

Outline of Final Research Achievements

We conducted a stereological analysis of the morphological characteristics in the placental basal plate with or without ART procedures.
Placental separation in the middle of the decidual layer commonly occurs after the delivery of neonates and is also referred to as the “separation zone”. We assessed the % loss of decidua in placentas and found that it was significantly higher in the frozen thawed embryo transfer in the hormonal cycle group than in the three other groups hematoma commonly forms at the “separation zone” in the decidual layer and markedly contributes to the amount of total bleeding in deliveries
we speculated that artificial endocrinological circumstances in early pregnancy, especially frozen thawed embryo transfer in the hormonal cycle group, may cause changes in the structure and/or function of the extracellular matrix in the decidual layer, as represented by the % loss of decidua, and causatively be associated with increased bleeding in deliveries.

Free Research Field

周産期医学　胎盤病理