An exploration of novel immunosuppressive factors by using immunological functional genome screening and development of new treatment strategy in ovarian cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670723
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: HAMANISHI Junzo 京都大学, 医学(系)研究科(研究院), 助教 (80378736)
• Co-Investigator(Kenkyū-buntansha): KONISHI Ikuo 京都大学, 大学院医学研究科, 教授 (90192062) ; MATSUMURA Noriomi 京都大学, 大学院医学研究科, 准教授 (20452336) ; ABIKO Kaoru 京都大学, 大学院医学研究科, 准教授 (20508246)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 卵巣がん / がん免疫抑制 / 機能ゲノミクス / 免疫療法 / がん免疫逃避

Outline of Final Research Achievements

We detected several immune suppressive genes, by using immunological functional-genome -screening for exploring a novel factors related to cancer immune escape in ovarian cancer. Some of these genes-transduced ovarian cancer cell line showed immunosuppressive function with co-cultured CD8+T cells. Therefore these data suggested that we found one of novel immunosuppressive mechanism in ovarian cancer via these genes. Hereafter, we will confirm this immuno- mechanism with in vivo mouse ovarian cancer model.

Free Research Field

医歯薬学