Development of novel anitiboday targeting periostin for the treatment of proliferative vitreoretinal diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670757
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyushu University
• Principal Investigator: Yoshida Shigeo 九州大学, 医学(系)研究科(研究院), 准教授 (50363370)
• Co-Investigator(Kenkyū-buntansha): ISHIBASHI TATSURO 九州大学, 大学病院, 病院長 (30150428)
• Co-Investigator(Renkei-kenkyūsha): HOSHINO YU 九州大学, 工学研究院, 准教授 (40554689)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: プラスチック抗体 / 網膜血管新生 / 脈絡膜血管新生

Outline of Final Research Achievements

We synthesized polymer nanoparticle libraries and performed screening to extract those polymer particles to inhibit periostin-dependent cell proliferation using in vitro cell proliferation assays. At the 2nd screening, we could extract Cation1-4, Cation1-5, Cation1-6 which inhibited cell proliferation in a dose-dependent manner. Among these polymer nanoparticles, Cation1-4 exhibited the significant inhibition of retinal and choroidal proliferation in vivo.

Free Research Field

眼科学