Analysis of genomic aberrations, risk of secondary cancer development and, hereditary effects by irradiation and chemotherapy in children

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670764
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Hiroshima University
• Principal Investigator: HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
• Co-Investigator(Kenkyū-buntansha): ONITAKE Yoshiyuki 広島大学, 大学病院, 病院助教 (10448269) ; KURIHARA Sho 広島大学, 大学病院, 医科診療医 (40724894)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: ゲノム / 癌 / マイクロアレイ / 小児 / 放射線

Outline of Final Research Achievements

Genomic aberration was analyzed in 27 childhood cancer survivors who underwent treatments in Hiroshima University Hospital after 1980 and could have their own children. Among them, 15 cases had genomic aberrations which were significantly correlated to whole body irradiation and high-dose chemotherapy in their history. The analysis of these aberrations in their children suggested the possibility that hereditary transmission occurred in 3 cases but the common characteristics were not identified in these 3 cases. And in 5 of 6 cases who had secondary malignancies had genomic aberrations.
These results revealed that genomic aberration due to cancer treatments were identified in the childhood cancer survivors and some of them were transmitted in their children.

Free Research Field

医歯薬学