The effects of DAMPs through C type lectin receptors on the wound healing

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670769
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Tohoku University
• Principal Investigator: Usuba Chie 東北大学, 医学(系)研究科(研究院), 非常勤講師 (80509232)
• Co-Investigator(Kenkyū-buntansha): TACHI Masahiro 東北大学, 医学系研究科, 教授 (50312004) ; KANNO Emi 東北大学, 医学系研究科, 講師 (10431595)
• Co-Investigator(Renkei-kenkyūsha): KAWAKAMI Kazuyoshi 東北大学, 医学系研究科, 教授 (10253973)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 創傷治癒 / 炎症 / C型レクチン受容体 / DAMPs

Outline of Final Research Achievements

We addressed the possible involvement of C-type lectin receptors (CLRs) in the wound site. The expression of CLRs (Mincle, Dectin-1, Dectin-2) mRNA in the wounded skin were increased after wound creation. We analyzed the role of caspase recruitment domain-containing protein 9 (CARD9), which is an essential signaling adaptor molecule in NF-κB activation upon triggered through CLRs. The percent wound closure, accumulation of leukocytes, mRNA expression of TNF-α were decreased in CARD9 KO mice. These results suggest that CLRs may involved in the inflammatory response at the wound site.

Free Research Field

形成外科学