A Study to Subjugate Bone Cycles using siRNA

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670773
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Nagasaki University
• Principal Investigator: YANO Hiroki 長崎大学, 病院(医学系), 講師 (60325652)
• Co-Investigator(Kenkyū-buntansha): TANAKA Katsuya 長崎大学, 病院(医学系), 客員研究員 (70722750) ; HIRANO Akiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90208835)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: miRNA / 骨形成 / 骨調整 / G蛋白質

Outline of Final Research Achievements

This study is primarily intended to control the bone cycle such as bone formation and resorption with siRNAs. Since miR-142 has related to immune system, we’ve gotten the results that it also contributes to the low-weight molecular G proteins operating cytoskeletal action based on the bioinformatics. Although miR-142 signals could not be found in the murine femur by in situ hybridization, miR-142-3p and miR-142-5p were newfound in immune cells by qPCR after cDNA cloning from miRNA extractions.

Free Research Field

形成外科学