2016 Fiscal Year Final Research Report
Skin grafting procedure considering collagen fiber orientation.
| Project/Area Number |
26670775
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | コラーゲン線維 / ラット / 皮膚移植 / 配向性 / マイクロ波方式 / 電子顕微鏡 |
|---|
| Outline of Final Research Achievements |
Few studies have reported collagen fiber orientation in the corium of animals. In this study, we investigated collagen fiber orientation in the rat skin using a microwave system (A). The results showed marked site-related differences. To examine the influence of skin grafting on collagen fiber orientation (B), we prepared skin grafts from two points of the rat skin, and implanted them in the same direction as the original site (Case 1) or in a 90-degree rotation of the original site (Case 2). After 3 months, the skin was prepared and grafted. Collagen fiber orientation in the skin graft was investigated using an electron microscope. In Case 1, it was similar to that in the surrounding areas. However, in Case 2, it differed from that in the surrounding areas, showing a 90-degree rotation. After skin grafting, graft survival on the graft bed may have been achieved, with graft orientation being maintained, suggesting the involvement of this phenomenon in skin contracture.
|
| Free Research Field |
形成外科学
|
