Development of the method which focus its attention on a stem-cell niche, for regenerating long-term form-retaing auricular cartilage by the piece transplantation of a perichondrium

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670780
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Kanazawa University
• Principal Investigator: KOMURO AKITO 金沢大学, 大学病院, 講師 (80387365)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 軟骨膜組織幹細胞・前駆細胞 / 幹細胞ニッチ / 血管新生

Outline of Final Research Achievements

We planned the study using the rabbit auricular cartilage paying our attention to stem cells and its maintenance mechanism to improve the long-term form maintainability that have been a problem of the auricular cartilage reproduction. But in own study for the rabbit rib perichondrium, it was found earlier that neovascularization occurred in a perichondrium before chondrogenesis.So we examined an association between angiogenetic inhibition and the chondrogenesis in this model. By administration of neovascularization inhibitor, the neovascularity in the perichondrium decreased and significantly the quantity of subsequent chondrogensis was inhibited. Because the growth and differentiation of the perichondrium cells thought to be the stem cells origin showed a correlation of the chondrogenesis, the neovascularization acted for the maintenance mechanism of the perichondrium stem/progenitor cells. It was suggested that the neovascularization in the perichondrium triggered the chondrogenesis.

Free Research Field

形成外科