2016 Fiscal Year Final Research Report
Effects of inhaled aerosolized insulin on acutely injured lungs.
| Project/Area Number |
26670783
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKAZAWA KOICHI 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (10207756)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | acute lung injury / insulin / blood glucose / ARDS |
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| Outline of Final Research Achievements |
The purpose of the present study is to clarify whether insulin exerts anti-inflammatory effects in acute lung injury under normoglycemia. Lung injury was induced by lung lavage. Mechanically ventilated rabbits were treated with either aerosolized insulin or saline. After 6 hours of treatment, the lungs were excised en bloc, and then we examined IL-8, TLR-4, or ENaCα mRNA expression in BALF cells or lung tissue. Aerosolized insulin failed to ameriorated inflammatory responses under normoglycemia, however, the tissue levels of mRNA expression of ENaCα were maintained by insulin. The results suggest that insulin might contribute to the lung fluid clearance via expression of epithelial sodium channel.
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| Free Research Field |
麻酔・集中治療医学
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