2015 Fiscal Year Final Research Report
Functional analysis of a novel immune signaling molecule involved in allergic response.
| Project/Area Number |
26670822
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO JUN-ICHI 福岡歯科大学, 口腔歯学部, 講師 (30509047)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 免疫・感染・炎症 / シグナル伝達 / 遺伝子 / 細胞・組織 / アレルギー |
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| Outline of Final Research Achievements |
T helper cells especially Th2 cells play a triggering role in the allergic response, including oral allergies. However, the mechanism underlying the differentiation of T helper cells into Th2 cells has not been completely elucidated. Our group has studied various signaling molecules controlling the differentiation of T helper cells. We found a novel signaling molecule, which was expressed specifically in Th2 cells during the differentiation of T helper cells. We investigated the characterization and function of the signaling molecule. The expression of the signaling molecule, as in Th2 cells, was not found in other types of T helper cells. The signaling molecule could have some functions in cytokine production and cell migration in T cells.
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| Free Research Field |
免疫細胞生物学
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