Fabrication of bone graft materials using iPS cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670835
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku University
• Principal Investigator: Egusa Hiroshi 東北大学, 歯学研究科(研究院), 教授 (30379078)
• Co-Investigator(Renkei-kenkyūsha): YATANI Hirofumi 大阪大学, 大学院歯学研究科, 教授 (80174530) ; FUKUMOTO Satoshi 東北大学, 大学院歯学研究科, 教授 (30264253)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 骨補填材 / iPS細胞 / 再生歯学

Outline of Final Research Achievements

iPS cells can be infinitely expanded and guided to differentiate into osteogenic cells. In this research project, we attempted to fabricate bone graft materials by inactivation of osteogenically-induced iPS cells. Embryoid bodies of mouse gingiva-derived iPS cells were used to fabricate osteogenic iPS cell constructs. We found that the size and calcium production of mouse gingiva-derived iPS cell constructs can be controlled under a floating culture condition to provide suitable characteristics as a bone grafting material that enables bone regeneration in an animal model.

Free Research Field

再生歯学