Therapeutic effect of human dental pulp stem cell on Experimental autoimmune encephalomyelitis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670837
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Okayama University
• Principal Investigator: Akiyama Kentaro 岡山大学, 大学病院, 講師 (70423291)
• Co-Investigator(Kenkyū-buntansha): KUBOKI TAKUO 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195) ; ONO MITSUAKI 岡山大学, 大学院医歯薬学総合研究科, 助教 (60613156) ; OSHIMA MASAMITSU 岡山大学, 大学院医歯薬学総合研究科, 助教 (00548307)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 歯髄幹細胞 / 難治性神経疾患 / 免疫寛容

Outline of Final Research Achievements

In this study，we evaluated therapeutic effect of human dental pulp stem cells (DPSCs) against experimental autoimmune encephalomyelitis (EAE) model mice. In comparison with human bone marrow derived mesenchymal stem cells (BMSCs) injection, DPSCs ameliorate clinical symptom including hind leg paralysis and immunological status (up-regulation of regulatory T cells and down-regulation of inflammatory Th 17 cells). However, the accumulation of injected cells into injured nerve system wasn't detected. Thus nerve regeneration mechanism still unclear.

Free Research Field

医歯薬学