Control of periodontitis and peri-implantitis by Lactobacillus-derived factor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670838
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hiroshima University
• Principal Investigator: Nikawa Hiroki 広島大学, 医歯薬保健学研究院(歯), 教授 (10228140)
• Research Collaborator: MINE YUICHI ; MIMURA SUMIYO ; UMEMOTO CHIKA ; MANABE AI ; OKADA CHIAKI
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インプラント周囲炎 / 抗菌ペプチド / プロバイオティクス / 歯肉上皮細胞 / 歯肉線維芽細胞

Outline of Final Research Achievements

Kog1 is derived from Lactobacillus rhamnosus KO isolated from a patient with no caries experience. Kog1 significantly inhibited the expression of inflammatory cytokines and chemokines induced by LPS of Porhyromonas gingivalis in gingival epithelial cells and fibroblasts. Kog1 highly bound to LPS. It is suggested that Kog1 binds and neutralizes LPS, resulted in the inhibitory effects as with known anti-microbial peptides.

Free Research Field

歯科補綴学