A novel design of metabolic target therapy in oral cancer cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670872
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Sapporo Medical University
• Principal Investigator: Ogi Kazuhiro 札幌医科大学, 医学部, 講師 (40433114)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖代謝阻害薬 / グルコーストランスポーター

Outline of Final Research Achievements

2 - DG (2 - deoxy - D - glucose), a glucose metabolism inhibitor takes into tumor cells, but the amount of uptakes are depending on the phenotype of tumor cells. In our study, we established mice xenograft models with oral squamous cell carcinoma cell line , and we examined the antitumor effect by the combination of radiotherapy with 2-DG. As a result, in the group of the combination of radiotherapy with 2-DG, there is a significant tumor growth suppression compared with the control group and 2-DG alone. Our study suggested that 2-DG has synergistic effects when combined with radiotherapy, which might lead to the design of an effective metabolic target therapy.

Free Research Field

口腔腫瘍