Development of therapy for osteoradionecrosis using the activation of osteoblast and hematopoietic stem cell

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670874
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Saitama Medical University
• Principal Investigator: Tsuyoshi Sato 埼玉医科大学, 医学部, 准教授 (60406494)
• Co-Investigator(Kenkyū-buntansha): Usui Michihiko 九州歯科大学, 歯学部, 准教授 (10453630) ; Mizuno Yosuke 埼玉医科大学, 医学部, 講師 (30406532)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 放射線 / 骨髄細胞 / 脂肪組織由来間葉系幹細胞 / 骨芽細胞 / 脂肪細胞 / 破骨細胞

Outline of Final Research Achievements

We examined whether FITC-(Asp-Ser-Ser)6 is a useful career for transfection into bone specifically and showed that it was incorporated to bone tissue. We found that osteoblastic gene was upregulated in irradiated bone marrow cells. On the other hand, not only co-culture osteoblastic gene but also adiogenic gene was upregulated and osteoclastic gene was downregulated in irradiated bone marrow cells co-cultured with adipose-derived mesenchymal stem cells.

Free Research Field

口腔外科学