Intracellular localization of SIRT1 in oral squamous cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670876
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: Ohtsu Takashi 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん治療学部, 主任研究員 (10270696)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: SIRT1 / 口腔扁平上皮癌

Outline of Final Research Achievements

SIRT1 is a gene with the role of both of a cancer suppressor gene and a oncogene. In our study of the oral squamous carcinoma, SIRT1 seems to act as a cancer suppressor gene in the nucleus, but as a oncogene in the cytoplasm. We aimed at the establishment of the prognostic prediction method of oral squamous carcinoma including SIRT1 and related genes by statistical analysis.
SIRT1 includes two nuclear localization signal (NLS) and two nuclear export signal (NES) sequences, and move between nuclear and cytoplasm. We made the SIRT1 genes introduced mutation into NLS and NES sequence to analyze this phenomenon. It was suggested that the NLS and NES sequence of SIRT1 listed in NCBI database should be reconfirmed.

Free Research Field

細胞生物学