Development of molecular targeted therapy for progressive condylar resorption using cell specific estrogen receptor knockout mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670882
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Moriyama Keiji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20262206)
• Co-Investigator(Renkei-kenkyūsha): NODA Masaki 東京医科歯科大学, 医学部, 非常勤講師 (50231725) ; OGAWA Takuya 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (50401360) ; HIGASHIHORI Norihisa 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50585221) ; KOBAYASHI Yukiho 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20596233)
• Research Collaborator: KADOTA Chiho (WATANABE Chiho) 東京医科歯科大学, 大学院医歯学総合研究科, 日本学術振興会特別研究員PD (30736658)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 下顎頭吸収 / エストロゲン / 軟骨細胞 / 破骨細胞 / 骨芽細胞

Outline of Final Research Achievements

Progressive Condylar Resorption (PCR) exhibits progressive mandibular retrusion and anterior open bite, which leads to decrease in quality of life. However, pathology and etiology of PCR are unclear. We investigated the effect of estrogen and other external factors on the mandibular condyle using new model mice to determine the mechanism of PCR pathogenesis. We found that turnover of bone metabolism was changed in the condyle of the young adult mice. Therefore, it is suggested that estrogen interacts with other external factors and plays an important role in maintaining condylar morphology.

Free Research Field

歯科矯正学