Restoration of tooth enamel by biomineralization with oyster shell nano-powder and enamel matrix proteins

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670885
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Tanimoto Kotaro 広島大学, 医歯薬保健学研究院, 教授 (20322240)
• Co-Investigator(Kenkyū-buntansha): KUNIMATSU Ryo 広島大学, 大学院医歯薬保健学研究院, 助教 (40580915) ; HIROSE Naoto 広島大学, 大学院医歯薬保健学研究院, 助教 (50611935) ; KEISUKE Sumi 広島大学, 大学院医歯薬保健学研究院, 助教 (00707078) ; YOSHIMI Yuki 広島大学, 大学病院, 歯科診療医 (50707081)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: バイオミネラリゼーション

Outline of Final Research Achievements

Recombinant human amelogenin formed nanosphere in solution at neutral pH. The surface roughness of tooth enamel surface was decreased significantly by the biomineralization treatment with amelogenin. Artificial plaque was removed effectively by the treatment with oyster shell nano-powder, whereas no obvious biomineralization effects were shown. A method to maintain oyster shell nano-powder onto enamel surface is considered to be necessary, and a further investigation to find better condition for biomineralization is desired.

Free Research Field

歯科矯正学