2016 Fiscal Year Final Research Report
Molecular Dynamics and basis of DNA tether structure for preventing radiation-induced chromosome fragmentation
| Project/Area Number |
26701006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
Miyamoto Tatsuo 広島大学, 原爆放射線医科学研究所, 講師 (40452627)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DNA修復 |
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| Outline of Final Research Achievements |
DNA double-strand breaks during mitosis are known to be difficult to be repaired because of the high condensation of mitotic chromosomes. Interestingly, a spindle assembly checkpoint (SAC) molecule BubR1 induces a DNA tether structure to prevent chromosome fragmentation post ionizing radiation (IR) in Drosophila neuroblasts. This study revealed that human BubR1 does not induce the DNA tether but suppress the chromosome fragmentation post IR in a SAC-independent manner. Taken together, BubR1-dependent protection of chromosomes post IR is conserved among species, but the molecular mechanism develops in an organism-specific manner.
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| Free Research Field |
放射線生物学
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