Molecular mechanisms of exercise-induced muscle hypertrophy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26702028
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Sports science
• Research Institution: Nagoya Institute of Technology (2015-2017); The University of Tokyo (2014)
• Principal Investigator: Ogasawara Riki 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (10634602)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 骨格筋 / タンパク質代謝 / シグナル伝達 / 筋収縮 / 翻訳調節 / mTOR / ラパマイシン

Outline of Final Research Achievements

We investigated the molecular mechanisms of exercise-induced muscle hypertrophy. Our data suggest that exercise-induced increase in muscle protein synthesis and muscle hypertrophy are mechansitic target of rapamycin (mTOR) signaling-dependent processes. Furthermore, both rapamycin-sensitive and -insensitive mTOR (rapamycin-insensitive mTOR complex 1 (mTORC1) and mTORC2) signaling regulate these event.

Free Research Field

運動生理学