2016 Fiscal Year Final Research Report
Investigation on how to prevent type 2 diabetes by the tolerance to adiposity
| Project/Area Number |
26702032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Toho University |
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Principal Investigator |
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| Research Collaborator |
SHIGIYAMA Fumika
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 非アルコール脂肪肝 / 肝インスリン感受性 / 高分子アディポネクチン / 脂肪組織インスリン感受性 |
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| Outline of Final Research Achievements |
Focusing on patients whose intrahepatic lipid content was >5% (n=26), we assessed putative markers in blood, body composition, tissue specific lipid accumulation by 1H-MRS, insulin sensitivity by hyperinsulinemic euglycemic clamp, pathological diagnosis and gene expression using liver biopsies, and the plasma metabolome. As results, H-IS assessed by % suppression of endogenous glucose production during the clamp was preserved in some NAFLD patients. Among all the parameters, citric acid, cis-aconitic acid, and succinic acid, which are the components of TCA cycle assessed by metabolome, adipose IS (% suppression of non esterified fatty acid during the clamp), and adiponectin were significantly higher in the upper tertile of H-IS than the lower (P<0.05). Interestingly, hepatic pyruvate carboxylase mRNA expression was 27% lower in the H-IS preserved group. In contrast, BMI, ALT, CRP, typeIV collagen, muscle IS, and tissue NAFLD activity score were not different between the two groups.
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| Free Research Field |
糖尿病・代謝・内分泌学
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