Nanoelectronics for multisite intracellular recording in brain tissue in vivo

2017 Fiscal Year Final Research Report

• Project/Area Number: 26709024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Electron device/Electronic equipment
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Kawano Takeshi 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (70452216)
• Research Collaborator: NUMANO RIKA 豊橋技術科学大学, 大学院工学研究科, 准教授 (30462716) ; KOIDA KOWA 豊橋技術科学大学, エレクトロニクス先端融合研究所, 准教授 (10455222)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ナノデバイス / 細胞内電極 / 細胞内計測 / シリコン / MOSFET / センシングデバイス

Outline of Final Research Achievements

In this research, it is aimed to develop a nanoscale needle device with the needle length of more than 100 μm, which length enables intracellular electrical measurement and DNA introduction into cell for thick biological tissues including brain slice and brain in vivo. In order to realize the > 100-μm-long nanoneedle devices, we have proposed the nanoscale-tipped silicon microneedle device by sharping the tip portion of the silicon microneedle, which can be vertically assembled on a silicon substrate by gold-catalyzed selective vapor-liquid-solid (VLS) crystal growth of silicon. The fabrication process is based on the silicon growth and subsequent micro/nanofabrication processes. We explored the mechanical and electrical characteristics of the proposed nanoelectrode, and demonstrated the intracellular recording capabilities using mouse’s muscle cells ex vivo and mouse’s brain tissue in vivo.

Free Research Field

電子デバイス・電子機器