Innovation of Super-early Cancer Diagnosis and Therapy Fundamentals by the Synthesis of Photofunctional Apatite Nanoparticles with Mesostructures

2016 Fiscal Year Final Research Report

• Project/Area Number: 26709052
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Structural/Functional materials
• Research Institution: Nagaoka University of Technology
• Principal Investigator: TAGAYA MOTOHIRO 長岡技術科学大学, 研究科, 准教授 (20621593)
• Research Collaborator: ABE SHIGEAKI 北海道大学, 歯学研究科, 助教 (40374566) ; SHIBA KOTA 物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究員 (20621593)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: セラノティクス / ナノバイオ材料 / ナノバイオセラミックス / 無機／有機ナノハイブリッド / 水酸アパタイト結晶核形成 / 生体親和性メソ多孔質構造 / 金ナノ粒子集積 / 高輝度バイオイメージング

Outline of Final Research Achievements

The detection and therapy techniques of at super-early stage cancer cells by biocompatible marker nanomaterials are desired. In this study, biocompatible and luminescent photofunctional apatite nanoparticles with mesostructures were successfully prepared for the diagnosis and therapy at the cellular scales. As a result, the nucleation and growth of photofunctional species and apatite precursors occurred on supramolecular assembly to form the mesostructred apatite nanoparticles. The ligand molecules that can selectively react with cancer cells were immobilized on the nanoparticles. The nanoparticles exhibit nontoxicity and specifically and effectively bind to cancer cells to resultantly induce the intense photoluminescence. By the exposure to different energy light, the cancer cells completely disappeared, suggesting that the nanoparticles worked only on the cancer. Therefore, this study provided the novel concept of the non-invasive theranotics for cancer diseases.

Free Research Field

生体ナノ材料化学