2016 Fiscal Year Final Research Report
Biochemical analysis of small RNA-induced epigenetic changes
| Project/Area Number |
26710011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 小分子RNA / トランスポゾン / 生殖細胞 |
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| Outline of Final Research Achievements |
More than 45% of human genome consists of transposons and its remnants. Transpositional events of them are deleterious to their hosts, especially in their gonads. Here, I am engaged in how small RNA would induce transcriptional silencing at transposon sequences, by using both fly and mouse systems. For fly system, I am trying to establish a method to proteomically identify the chromatin components at specific genomic region. For mouse system, I have profiled the chromatin dynamics in the small number of germ cells within the whole testis, and comprehensively described its temporal change in detail, particularly at transposon sequences.
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| Free Research Field |
エピジェネティクス
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